Journal of Clinical and Advanced Medicine
Welcome to the Journal of Clinical and Advanced Medicine (JCAM) The Journal of Clinical and Advanced Medicine (JCAM) is an international, peer-reviewed, open-access journal dedicated to publishing high-quality, impactful advancements across the broad spectrum of medical sciences. Published under the institutional aegis of NEO-ART EXCELLENCE HUB PRIVATE LIMITED, JCAM serves as a premier global forum for clinicians, oncologists, pediatricians, surgeons, pharmacologists, and healthcare researchers. Bridging Clinical Excellence and Medical Technology In an era of rapid scientific transformation, JCAM focuses on bridging the gap between conventional clinical practice and cutting-edge healthcare innovations. The journal prioritizes translational research in molecular medicine alongside modern applications of Artificial Intelligence (AI), machine learning, and digital diagnostics in clinical care. Journal Logistics & Metadata Journal Title: Journal of Clinical and Advanced Medicine Acronym: JCAM ISSN: Pending Assignment Publication Frequency: Continuous Publication (Compiled into 2 Issues Per Year) Format: Online Only Peer Review Policy: Double-Blind Peer Review (15 to 21 days evaluation window) Plagiarism Threshold: Max 15% similarity index (Strictly enforced via digital screening) Access Model: Gold Open Access (CC BY 4.0 License) Publisher: NEO-ART EXCELLENCE HUB PRIVATE LIMITED, Visakhapatnam, Andhra Pradesh, India Call for Papers JCAM invites authors to submit their original research, comprehensive reviews, illustrative case reports, short communications, and authoritative editorials. There are no submission fees. Authors retain full copyright ownership under the CC BY 4.0 framework. [Submit Your Manuscript Online] [Browse Author Guidelines]
All articles published in the Journal of Clinical and Advanced Medicine (JCAM) are licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This license allows anyone to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material) for any purpose, even commercially, as long as appropriate credit is given to the original author(s) and the source. License link: https://creativecommons.org/licenses/by/4.0/
Using Tai Chi and Qigong to Treat Parkinson’s Disease: Utilizing Artificial Intelligence to Summarize 7 Traditional Chinese Medicine Studies
Parkinson’s disease is characterized by progressive motor impairment and a wide range of non‑motor symptoms that remain only partially controlled by conventional pharmacotherapy. Tai Chi and Qigong, two traditional Chinese mind–body practices, have been increasingly investigated as complementary approaches for patients with Parkinson’s disease. This article uses an artificial intelligence assistant to collate and summarize findings from 7 key publications—primarily systematic reviews, meta‑analyses, and randomized controlled trials—together with additional recent clinical and mechanistic studies on Tai Chi and Qigong in this population. Across these reports, Tai Chi and Qigong are consistently associated with improvements in balance, postural stability, functional mobility, and fall rates, with several trials also demonstrating benefits in motor scores, sleep, mood, cognition, and health‑related quality of life. Emerging mechanistic work suggests that these practices may exert their effects through enhanced neuromuscular control, modulation of brain network connectivity, anti‑inflammatory and antioxidant pathways, and improved neuroplasticity. At the same time, the evidence base remains constrained by heterogeneous protocols, limited long‑term follow‑up, and variable methodological quality in some reviews. Overall, current data support Tai Chi and Qigong as safe, feasible, and potentially valuable adjuncts to standard care for Parkinson’s disease, and highlight the utility of artificial intelligence tools for efficiently synthesizing an evolving literature.
Copyright (c) 2026 Copyright © 2026 by the Author(s). Published by Neo-ART Excellence Hub Pvt. Ltd. This article is distributed under the Creative Commons Attribution 4.0 License (CC BY 4.0). Authors retain copyright and grant the publisher the right to publish and distribute the work. https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/
A Sample Protocol for Using Tai Chi and Qigong to Treat Parkinson’s Disease: An Application of Artificial Intelligence to Traditional Chinese Medicine
Background: Parkinson’s disease is associated with motor symptoms such as bradykinesia, rigidity, tremor, and postural instability, as well as non‑motor features including fatigue and mood disturbance, and quality of life in people with Parkinson’s disease, but detailed, PD‑specific protocols are limited.​ Objective: To describe a sample Five Animals Qigong protocol for adults with mild‑to‑moderate Parkinson’s disease, developed with the assistance of artificial intelligence and refined by the author, that can serve as a structured yet adaptable template for clinical practice and research.​ Methods: An AI assistant (Grok 4) was instructed to generate a Five Animals Qigong program targeting core PD impairments, including postural instability and motor slowness, and control conditions, and primary and secondary endpoints.​ Results: The protocol proposes an 8‑week intervention consisting of 20‑minute Five Animals Qigong sessions three times per week, incorporating a brief warm‑up, three core postures The trial design specifies the Unified Parkinson’s Disease Rating Scale Part III as the primary outcome, with secondary measures including the Berg Balance Scale, 10‑Meter Walk Test, fatigue, quality of life (PDQ‑39), heart rate variability, and perceived exertion.​ Conclusions: This AI‑assisted Five Animals Qigong protocol offers a detailed, PD‑focused example of how traditional Chinese exercises can be structured for use in Parkinson’s disease management and evaluated in randomized controlled trials. The approach outlined here may be extended to other tai chi and qigong forms and neurological conditions, helping to bridge traditional mind–body practices with contemporary evidence‑based rehabilitation.​
Comparative Evaluation of the Phenolic Content, Antioxidant Properties, and Antidiabetic Effects of N-Butanol Extracts of Ficus exasperata Leaf and Nigella sativa Oil in Diabetic Drosophila melanogaster
Oxidative stress plays a key role in the pathogenesis of diabetes mellitus, and plant-based antioxidants have shown potential in diabetes management. Research has demonstrated the ethnomedicinal uses and pharmacological activities of Ficus exasperata and Nigella sativa oil in ameliorating various health conditions. This study evaluated and compared the phenolic content, antioxidant capacity, and antidiabetic effects of n-butanol extracts of Ficus exasperata leaf and Nigella sativa oil. The extracts in vitro antioxidant properties were assessed through total phenolic content (TPC), DPPH radical scavenging, and ferric reducing antioxidant power (FRAP) assays, while the antidiabetic effects were evaluated by measuring glucose levels and total thiol concentrations in diabetic flies treated with n-butanol extracts of Ficus exasperata and Nigella sativa oil in vivo. Both extracts exhibited significant antioxidant activity and effectively reduced hyperglycemia while restoring total thiol levels with the n-butanol extract of Ficus exasperata offering the best effects characterized by higher phenolic content and DPPH radical scavenging activity. The Nigella sativa oil showed greater ferric reducing antioxidant power. The higher phenolic contents, DPPH radical inhibition, and restoration of total thiol concentration and significant reduction of glucose level demonstrated by the n-butanol fraction of Ficus exasperata, makes it the recommended fraction for further therapeutic exploration. Future studies should focus on isolation and characterization of its active compounds and assess long-term efficacy and safety in more comprehensive models.
Concurrent Hürthle cell and Papillary thyroid carcinoma in a survivor patient of breast cancer: case report
Our patient was a 37-year-old woman with a history of advanced breast cancer. She initially presented to the general surgery Department in the sur hospital on april 9th 2022 with a Solitary nodule, Right lobe thyroid. Clinically euthyroid. Utrasound imaging and subsequent FNAC report showed right lobe nodule suspicious for follicular neoplasm Hürthle cell type (Thy3f), Bethesda IV .She had a total thyroidectomy by endocrine surgeon. Post operative period was uneventful and patient recovered smoothly. Histopathology report post total thyroidectomy showed right lobe Hürthle cell carcinoma encapsulated angioinvasive measurement 13mm with vascular invasion but no capsule invasion pathologic stage (AJCC 8th edition). left lobe papillary thyroid carcinoma,(microcarcinoma 3mm). one lymph node identified at the isthmus negative for metastasis. Conclusions: thyroid malignancy in patients with breast cancer is not an uncommon occurrence. The vice versa also reported but less common.The concomitant occurrence of papillary thyroid carcinoma and Hürthle cell thyroid carcinoma and the exact diagnosis of this uncommon event are important. Mixed or collision tumors in thyroid seems To be on the rise.
Urinary Peritonitis After Inguinal Herniorrhaphy
*]:pointer-events-auto scroll-mt-[calc(var(--header-height)+min(200px,max(70px,20svh)))]" dir="auto" tabindex="-1" data-turn-id="request-WEB:dce06a26-9bd6-441d-beda-4e834335b647-5" data-testid="conversation-turn-12" data-scroll-anchor="true" data-turn="assistant"> Urinary peritonitis is a rare but serious complication resulting from intraperitoneal bladder rupture, most commonly due to trauma or iatrogenic injury. Bladder injury during inguinal hernia repair is uncommon but may occur, particularly in cases of unrecognized inguinal bladder hernia. We report the case of a 64-year-old man who developed urinary peritonitis five days after right inguinal herniorrhaphy. He presented with painful abdominal distension, generalized peritoneal irritation, anuria, and acute renal impairment. Imaging revealed intraperitoneal bladder rupture with a urinoma. Exploratory laparotomy confirmed a large bladder wall defect with massive uroperitoneum. Surgical repair with two-layer cystorrhaphy and drainage was performed, with favorable postoperative outcomes. This case highlights the diagnostic challenges of postoperative urinary peritonitis and emphasizes the importance of suspecting bladder involvement during inguinal hernia repair. Early recognition and prompt surgical management are essential to prevent severe complications.
Sinus Floor Elevation: A Retrospective Study of 59 Cases from the Oral Implantology Department of the Central Military Hospital-Algiers
Introduction: Implant placement in the posterior atrophic maxilla sometimes represents a challenge and requires pre-implant sinus floor elevation surgery. The objective of this study was to evaluate the success rate of sinus floor elevation techniques performed using the lateral and crestal approaches. Materials and Methods: A retrospective study was conducted on 59 cases. Two surgical techniques were used: 32 patients underwent the crestal approach, whereas 27 patients were treated using the lateral approach. Results: The success rate of the crestal sinus lift technique was 93.84%, with a failure or complication rate of 6.16%. The complications included two cases of sinus membrane perforation, one case of vestibular cortical plate fracture, and one case of implant instability. For the second technique, the success rate was 90.56%, with six failure cases, represented by three cases of membrane perforation, two cases of sinusitis, and one case of hemorrhage due to injury of the alveolo-antral artery. Conclusion: Mastery of the sinus lift technique enables initiation of implant treatment and helps meet patients’ expectations.
Copyright (c) 2026 Copyright © 2025 by the Author(s). Published by Neo-ART Excellence Hub Pvt. Ltd. This article is distributed under the Creative Commons Attribution 4.0 License (CC BY 4.0). Authors retain copyright and grant the publisher the right to publish and distribute the work. https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/
Complicated History of a Shoulder in a Diabetic Adult: Staphylococcus aureus Infection Following Local Corticosteroid Infiltration in a Shoulder with an Unrecognized Parsonage–Turner Syndrome: A Case Report
Painful shoulder is a common reason for consultation in adults, often presenting as degenerative pseudo-paralysis (1). Nevertheless, etiologies are multiple, including neurological causes (1), which may result in true paralysis. We report the case of a 67-year-old diabetic patient who developed an infection of the right shoulder following corticosteroid infiltration. Etiological investigation concluded in a Parsonage–Turner syndrome that had been mistakenly considered a degenerative disorder. We emphasize the atypical nature of this clinical case, as no similar cases were found in the literature.
Clinical Validation of the Tremoflo C2 Versus Tremoflo C100 in Asthmatic Patients 2-7 Years of Age
Background: Tremoflo C2 is an effort-independent oscillometer successor to C100 and measures resistance and reactance. Our objectives are to assess the reliability between two devices, compare Small Airway Dysfunction (SAD) identification in young asthmatic children, and evaluate device acceptance, feasibility and usability in this age group. Methods: In 53 asthmatic children 2-7 years, three sets of valid measurements were obtained for R7, R7-19, AX, and X7. SAD was defined as z-scores exceeding 1.645 residual standard deviations. After completion, patients and operators provided feedback. Single measure Intraclass Correlation Coefficient (ICC) determined whether C2 was as acceptable as C100. Bland-Altman analyses examined agreement and proportional bias. The McNemar test evaluated whether the proportion of SAD patients differed significantly between the two tools. Results: In our study population, 84.9% had mild asthma and 86.8% were well-controlled. Overall ICC indicated good device reliability, and proportional bias was seen only for R7-R19 (β=0.214 (95% CI .039, .388), p=.017). SAD was identified in 47.2% using the C2 device, 49.1% with the C100, (p=1.00). Patients and operators preferred C2 over C100. Conclusion: In our young, predominantly well-controlled, mild asthmatics, the C2 and C100 devices showed good agreement, usability, and preferability of C2 to identify SAD.
Impulse oscillometry metrics differentiate adults with asthma from non-asthmatic controls: a meta-analysis
Background Impulse oscillometry (IOS), an effort-independent technique, assesses both central and peripheral airway function. The latter are major sites of inflammation in asthma, suggesting that IOS may help diagnose asthma. However, previous IOS studies, limited by sample size, report mixed results. Our objective was to establish whether IOS-based airway metrics can differentiate adults with asthma from non-asthmatic subjects. Methods A meta-analysis of 11 published oscillometric studies was performed including adult (18-70 years) patients with well-controlled asthma and non-asthmatic controls. Sensitivity analysis was applied to assess the degree of heterogeneity. In addition, Minimal Clinical Important Difference (MCID) was determined. Results There were no significant differences in general demographics between study populations, consisting of 410 asthma patients and 211 controls. Significant differences between study populations were observed for FEV1 % predicted and all IOS metrics, with highly significant SMD differences for R5 -0.88 (p<0.0001), R5-R20 -0.85 (p<0.0001), X5 -0.78 (p<0.0001), and AX -1.15 (p=0.0300). The MCID for R5 was 0.046 kPa/L/s, R5-R20 0.013 kPa/L/s, X5 -0.022 kPa/L/s, and AX 0.088 kPa/L. Conclusion IOS-determined airway resistance (R5, R5-R20) and reactance (X5 and AX) can differentiate individuals with (controlled).
Adverse reactions to food in children; prevalence, clinical manifestations and risk factors, a population-based study
Background: Adverse reactions to food are common events which generally occur in early childhood and usually result in stress and anxiety not only in the child, but also in babies’ parents or caregivers especially because occasionally it leads to life-threatening reactions such as anaphylaxis. Materials& Methods: A cross-sectional population-based study has performed in south of Tehran, capital of Iran in 450 less than seven years old children to determine the prevalence, clinical manifestations and risk factors of Food allergy by interviewing the mothers based on a structured questionnaire. The children attended in 5 health centers to perform health care, growth and development monitoring or vaccination have selected conveniently. Findings: The prevalence of FA was 20% (88 cases) which included 49(56%) females and 39(%) males. The age range of the most involved children was 24-72 months. The most frequent food causing FA included egg cow milk (14 cases, 16%), and tree nuts(8 cases, 9%). Dermatologic symptoms were the most frequent adverse reactions to foods (48 cases, 54%). Conclusion: Though most of the findings of this study are in favor of other reports, performing large scale prospective cohort studies is highly recommended in order to obtain reliable results and confirm the findings.
Kala-azar disease in a 5- month- old male, a case report and review of the literature
Abstract: Background: Kala azar is a chronic parasitic disease which is prevalent in children such as adults, however, the number of in detail reports about the clinical manifestations, diagnostic methods and the treatment options in small babies are very limited. In this study, an under 6- month- old male and his characteristics have been described. Case presentation: A five month and 6 days male has admitted to the pediatric ward, because of 12 days’ fever, anorexia, weight loss and weakness. His physical examination findings included malaise and splenomegaly. Remarkable results in his laboratory tests have contained pancytopenia, negative results of all the performed related cultures and serologic tests. The diagnosis has been made by observing the bone marrow smear which included lots of Leishman body as extracellular and intracellular parasites within macrophages. He has responded to daily 3mg/kg Amphotericin B Liposomal for 7 doses as cumulative doses of 21mg/kg without occurring any adverse reactions or recurrence. Conclusion: It sounds that the clinical presentation, diagnosis and treatment protocols for Kala azar disease in infants should be more studied and reported because of the several challenges this age group of children confronted to, such as different combinations of clinical presentations, protocols.
Lung Cancer: A Comprehensive Review of Etiopathogenesis, Molecular Stratification, and the Paradigm Shift in Precision Oncology
Lung cancer remains the preeminent global oncologic challenge, maintaining its status as the leading cause of cancer-related mortality alongside a significant epidemiological shift toward developing nations. This comprehensive review explores the complex etiopathogenesis of the disease, highlighting the interplay between tobacco-induced epigenetic modifications and chronic inflammation within the tumor microenvironment. The article details the evolution of pathological classification, specifically the transition toward standardized TNM staging for Small Cell Lung Cancer (SCLC) to guide increasingly complex multimodal care. A major focus is placed on the paradigm shift in Non-Small Cell Lung Cancer (NSCLC), where molecular profiling has transformed from an advanced-stage necessity to an early-stage imperative. The review analyzes the impact of landmark trials, such as ADAURA and ALINA, which established the efficacy of adjuvant targeted therapies. Furthermore, it examines the expanding landscape of actionable genomic drivers—including EGFR, ALK, and the historically undruggable KRAS G12C—and the strategies utilized to overcome acquired resistance. Finally, the author discusses emerging therapeutic frontiers, including the rise of Antibody-Drug Conjugates (ADCs), the potential of Personalized Cancer Vaccines (PCVs) for eliminating minimal residual disease, and the clinical utility of liquid biopsy (ctDNA) for dynamic tumor profiling.
Apocrine Carcinoma of the Breast: A Case Report and Review of the Literature
Background: Apocrine carcinoma of the breast is a rare and distinct subtype of invasive ductal carcinoma characterized histologically by large tumor cells with abundant eosinophilic granular cytoplasm and prominent nucleoli. Accurate diagnosis and immunohistochemical profiling are essential for distinguishing this entity from other breast cancer subtypes. Emerging evidence suggests a potential therapeutic role for androgen receptor (AR)-targeted treatments in managing this disease. Case Presentation: The patient was a 55-year-old woman with no significant past medical history who presented for a routine physical examination. A screening mammogram revealed a 1.2 × 0.8 × 0.6 cm superficial mass in the upper outer quadrant of the right breast, along with scattered coarse microcalcifications. A core needle biopsy was performed, and histopathological analysis confirmed the diagnosis of apocrine carcinoma of the breast, a rare subtype of invasive ductal carcinoma. Immunohistochemistry (IHC) demonstrated strong androgen receptor (AR) positivity and negativity for estrogen receptor (ER), progesterone receptor (PR), and HER2. Conclusions: Through a review of the current literature, we highlight the key histopathological, molecular, and clinical features of apocrine breast carcinoma.
Copyright (c) 2025 Copyright © 2025 by the Author(s). Published by Neo-ART Excellence Hub Pvt. Ltd. This article is distributed under the Creative Commons Attribution 4.0 License (CC BY 4.0). Authors retain copyright and grant the publisher the right to publish and distribute the work. https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/
Beyond the Endoscope: Unmasking the Hidden Cause of Chronic Watery Diarrhoea in a Middle-Aged Lady-from IBS-D to Microscopic Colitis
Microscopic colitis is a chronic inflammatory disease of the colon that is characterized by chronic, watery, non-bloody diarrhea. It typically occurs in middle-aged patients and has a female preponderance. The colon appears typically normal or almost normal on colonoscopy in patients with microscopic colitis. The diagnosis is established by biopsy of the colonic mucosa demonstrating characteristic histologic changes. Microscopic colitis has two main histologic subtypes, lymphocytic colitis, more specifically defined in 1989, and collagenous colitis. It is treatable, but in the developing world, its diagnosis may often prove difficult. Data and reports of this condition in Bangladesh are scarce because most medical centers lack a functional gastrointestinal endoscopy unit that would aid in the diagnosis. We here in present a case of a 55-year-old lady who was getting treatment for refractory Irritable Bowel Syndrome-Diarrhea (IBS-D). Eventually she was diagnosed with lymphocytic microscopic Colitis. She started treatment with steroid, cholestyramine, later with azathioprine and improved dramatically.
Formulation And Evaluation of Herbal Cream Containing Azadirachta Indica for Antifungal, Antibacterial Activity
Development and Evaluation of a Polyherbal Cream Containing Ajwain, Betel Leaf, Neem Oil, and Tea Tree Oil for Relief of Vaginal Irritation and Associated Yeast Infections. Vaginal irritation and yeast infections are common gynecological issues affecting women's quality of life. Current treatments often have limitations, including antibiotic resistance and side effects. Our objective is to formulate and evaluate a polyherbal cream containing Ajwain (Trachyspermum ammi), Betel Leaf (Piper betle), Neem Oil (Azadirachta indica), and Tea Tree Oil (Melaleuca alternifolia) for relief of vaginal irritation, itching, and soreness associated with yeast infections. The polyherbal cream is a safe and effective treatment for vaginal irritation and associated yeast infections, offering a natural alternative to conventional treatment.
Madhuja NW, Pratiksha MG, Akanksha BR, Shivdhan BS, Rutuja AJ, Shravani DZ, Sakshi HK
Hormonal Genetic Synergy-Induced Regression of Prostate Adenocarcinoma
Hormonal therapy is the standard treatment for advanced androgen-dependent prostate adenocarcinoma. If tumor regression is not achieved early, the adenocarcinoma inevitably evolves toward androgen independence. This is due to the development of resistance mechanisms and the incomplete tissue-level cessation of androgen deprivation. Current research is focused on combined therapeutic strategies that will increase the effectiveness of androgen deprivation and delay recurrence. Androgen deprivation through hormonal therapy combined with genetic therapy can induce tumor regression by reducing angiogenesis and enhancing mitotic arrest and apoptosis. A study by the Intergroup in the United States has demonstrated a method for hormonal and genetic restoration of altered prostate cancer patterns resulting from intergenic suppression. This is due to mutations that alter the process by which the genetic information of a mutated gene is expressed. This highlights the urgent need to combine hormonal and genetic therapeutic approaches and expand our current understanding of molecular mechanisms. Epigenetic changes are considered key factors in prostate cancer treatment. Studies have shown that targeting epigenetic enzymes or regulatory proteins halts cancer cell division. Combining hormonal and genetic therapeutic approaches leads to induced regression of prostate adenocarcinoma.
Evidence Based Medicine in Pediatric Surgery
Evidence-based medicine is the conscientious, unquestionable, and basic application of the finest accessible prove in making choices almost the care of an individual patient. Evidence-based clinical practice implies connecting the individual clinical encounter of the doctor and the esteem systems of the doctor and quiet with the most excellent accessible prove from the therapeutic writing, which has developed from inquire about conducted concurring to strict methodological standards. The reason of evidence-based medicine is to make strides the quality of health care by recognizing and advancing the most excellent clinical practices and eliminating those that are incapable or indeed destructive.
T-Optimality for Model Discrimination in Non-Nested Models (medical studies)
T-optimality is a design criterion in model discrimination, aiming to maximize the power of a statistical test distinguishing between competing regression models. This article explores the use of T-optimality in the context of non-nested models, which do not share a common parameter space. We present the mathematical formulation, discuss its statistical properties, provide algorithmic considerations, and illustrate with numerical examples. Applications span medicine, engineering, and economics, where selecting the best predictive model is crucial.